With the increasing popularity of GLP-1s like Ozempic and Wegovy, it's essential to understand the comparative benefits and limitations of these treatments. While GLP-1s can be lifesaving for some, they have been sorely over-prescribed, and the negative side effects are becoming even clearer. 

We offer nutrition-based programs that center around the science of the Fasting Mimicking Diet (FMD) to reverse diabetes and metabolic conditions. Unlike the continuous pharmaceutical interventions of GLP-1s, our programs use FMD in conjunction with dietetic guidance, university tested-protocol, and physician oversight to provide a non-invasive, 360-degree approach to address the root causes of metabolic conditions for a specified period of time. In comparing the differences between GLP-1s and our FMD-centered plans, the FMD’s benefits prove to offer a more manageable, sustainable, and root cause-centered solution to obesity, metabolic conditions, blood sugar management, and diabetes. 

How They Work

The way in which GLP-1s and the FMD work within the body are vastly different. GLP-1s are pharmaceuticals that mimic the natural GLP-1 hormone, increasing insulin secretion (which pulls glucose into the cells), decreasing glucagon secretion (which breaks down glycogen in the liver), and slowing gastric emptying in the stomach (which ignites a feeling of fullness and satiety). The combination of its physiological mechanisms impact hormone levels to control appetite and glucose metabolism. 

In contrast, the FMD works by mimicking the effects of a prolonged 5-day fast while still providing essential nutrients. This triggers autophagy, setting off a broad range of metabolic and cellular responses that have been shown, over time, to potentially reduce insulin levels, aid in better blood sugar control, promote fat-targeted weight loss (with preserved muscle mass), and improve overall metabolic health. 

When FMD is delivered under the supervision of a doctor as part of a comprehensive lifestyle medicine program, diabetes medications can be safely de-prescribed towards diabetes remission. The FMD has also been shown to contribute to behavior change such as increased motivation both to exercise and to make better food and lifestyle choices, both essential for sustainable change.

Effects on Muscle Mass

Muscle mass plays a critical role in glucose management, as well as in the prevention and management of diabetes and other metabolic conditions. Muscle tissues are major sites for glucose uptake and storage, with higher muscle mass enhancing the body's capacity to store glucose, thereby improving insulin sensitivity and reducing the risk of insulin resistance. Since muscle tissue is metabolically active, increasing the basal metabolic rate (BMR = the number of calories needed to keep you alive) and aiding in weight management are crucial for sustained weight loss and diabetes prevention. Therefore, maintaining muscle mass is crucial in achieving sustained metabolic and weight management results.

One of the major benefits of FMD over GLP-1s is its muscle protection and preservation. While GLP1-s may be effective for weight loss, the use of these medications does not specifically target fat loss. In fact, up to 40% of the weight loss from GLP-1 use, on average, comes from the loss of lean tissue, including muscle mass. This is incredibly problematic for people who wish to eventually stop taking GLP-1s, as it can worsen body composition with each cycle; users may lose muscle while on GLP-1s and gain fat while off. The FMD, on the other hand, was specifically designed to preserve and protect lean body mass while targeting fat loss. Recent research shows no significant change in muscle mass during FMD use, which is crucial for maintaining metabolic health and physical function.

Administration

While GLP-1s are widely prescribed, their continuous use can pose challenges for many individuals. One of the main reasons for this is that treatments are continuous and require daily or weekly injections (some are available as oral tablets taken daily). These treatments require medical prescriptions and regular medical oversight to monitor efficacy and adjust dosages. 

The FMD protocol itself, as part of a comprehensive program, offers a non-invasive, drug-free alternative that requires only five days of a dedicated eating plan per month for a recommended period (either four consecutive months in a six month program or six consecutive months in a twelve month). These programs are comprised of 360 degree support that is personalized, dietitian guided, and medically supervised, ensuring that participants are not only following the eating plan but are also educated and supported throughout their health journey; GLP-1 treatments, however, often leave patients without this level of comprehensive care or support - a major shortcoming. The L-Nutra Health Programs, using the FMD approach, offer a more user-friendly, less intrusive, and finite approach, compared to continuous pharmaceutical treatments that lack guidance or support.

Risks, Considerations, and Compliance

Potential risks and compliance issues can directly impact the safety, effectiveness, and sustainability of health strategies, affecting the long-term success of treatment. The common side effects of GLP-1s, which include nutritional deficiencies and gastrointestinal issues such as nausea, vomiting, changes in bowel habits, and potential risks for pancreatitis and gallbladder disease, may make its usage difficult to maintain or continue. Furthermore, strict compliance with medication schedules, lifestyle modifications, and regular medical supervision are crucial for the efficacy and safety of GLP-1s, also posing serious adherence challenges.

While the FMD requires a five-day commitment to a dedicated eating plan, which some may find challenging, it offers a user-friendly regimen, with dietitian-guided support. Easy-to-follow pre-packaged meal kits with the support of a dietitian coach make it convenient and manageable to incorporate into one’s lifestyle. During the five days, participants may experience hunger and fatigue, in addition to common symptoms that result from the body adapting to using different energy systems (like ketones) for fuel, such as  headaches, dizziness, or difficulty concentrating; however, these side effects tend to lessen with repeated cycles as the body becomes more adept at burning fat and transitioning to ketosis. 

Expense

Expense of a treatment directly affects an individual's ability to maintain it long-term, and cost is one of the major barriers for GLP-1s; without insurance, they range from $800 to $1,200 monthly, and shortages may potentially drive costs even higher. With insurance, copays vary widely, and additional costs include regular doctor's visits, potential side effect management, and supplementary medications or treatments. Furthermore, these costs are continual, as there is no set end date for treatment with GLP-1’s.

Our programs that incorporate the FMD, on other hand, range from $99 to $299 per month and have a set end date, after either six or twelve months. The monthly rate includes the FMD kits, dietitian oversight, quarterly lab tests and analysis, medical supervision (for type 2 diabetes) and more - with no added or hidden costs. Unlike GLP-1s, there are fixed, set time frames for these programs, making them a more financially predictable and manageable option; in knowing how long they will need to follow the protocol, participants are set up for a higher compliance and success rate. 

For those struggling with blood sugar management, obesity, prediabetes, or diabetes, our L-Nutra Health Metabolic and Diabetes Remission and Regression Programs, which center around the power and science of the FMD, offer an effective, sustainable, non-invasive, and cost-efficient solution. 

Consulting with healthcare professionals to tailor a personalized approach is essential for achieving optimal outcomes—contact us now and begin your journey.